CSF levels of synaptosomal-associated protein 25 and synaptotagmin-1 in first-episode psychosis subjects.

• Post-mortem studies consistently show evidence of reduced synaptic protein levels in patients with schizophrenia. Clinically high-risk subjects show a steeper decrease in grey matter thickness and in vitro modeling using patient-derived cells implicate excessive synaptic pruning during neurodevelopment as a part of the schizophrenia pathophysiology. However, it is unclear to what extent synapse elimination is present during various stages of the disease, which is of clinical importance as in a real-world setting most subjects received their first-episode psychosis (FEP) diagnosis not until their mid-twenties. In the present study, we measured cerebrospinal fluid (CSF) concentrations of the two pre-synaptic proteins synaptosomal-associated protein 25 (SNAP-25) and synaptotagmin-1 (SYT-1), both of which are increased in conditions of ongoing synaptic degeneration, in 44 FEP subjects (mean age 29.9 years) and 21 healthy controls (25.9 years) using immunoprecipitation mass spectrometry. Neither protein was found to differ between healthy controls and patients, and they showed no correlation with symptom ratings, cognitive performance or antipsychotic medication. Additional studies in high-risk subjects in the early prodromal phase will be needed to address if excessive synapse destruction occurs before the development of overt psychotic symptoms.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Keyword

BACS-SC

Brief Assessment of Cognition in Schizophrenia Symbol Coding

BMI

body mass index

BVMT-R

Brief Visuospatial Memory Test-Revised

CGI

Clinical Global Impression

CPT-IP

Continuous Performance Test-Identical Pairs

DUP

duration of untreated psychosis

FEP

first-episode psychosis

GAF

Global Assessment of Functioning

HC

healthy controls

HVLT-R

Hopkins Verbal Learning Test-Revised

LNS

Letter-Number Span

MSCEIT

Mayer–Salovey– Caruso Emotional Intelligence Test

NAB: MAZES

Neuropsychological Assessment Battery: Mazes

PANSS

the Positive and Negative Syndrome Scale

SNAP-25

SYT-1

Schizophrenia

Synapse pruning

TMT

Trail Making Test

WMS-III

Wechsler Memory Scale-3rd Edition

Schizophrenia

SNAP-25

Synapse pruning

SYT-1

Publication and Content Type

ref (subject category)

art (subject category)